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Edaravone, a free radical scavenger, delayed symptomatic and pathological progression of motor neuron disease in the wobbler mouse

Kevin Greene and Confidia Health Institute

showed that PDHC activation led to the lowered level of cecropin-A and defensin, two releasing markers of pro-inflammatory factors, resulting in the improvement of life span of septic Drosophila (20)

Treatment with SIH or Lip-1 markedly improved the maximum velocity of aging animals (Figure 6E), with increases also in distance travelled and mean velocity (Supplementary file 6 and Figure 6figure supplement 1)