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In murine models, NNMT knockdown did not induce the accumulation of NAM in livers and adipose tissues, nor did it cause significant alterations in the intracellular levels of NAD + in hepatocytes ( + is not necessary for this regulatory process

Neelakantan H, Vance V, Wetzel MD, Wang H-YL, Mchardy SF, Finnerty CC, Hommel JD, Watowich SJ (2018) Selective and membrane-permeable small molecule inhibitors of nicotinamide N -methyltransferase reverse high fat diet-induced obesity in mice

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