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RPE cells are responsible for phagocytosing and digesting the membrane discs of the outer segments of photoreceptor cells, a critical component of the visual cycle

Quantitative analyses indicate that more than 60% of cytoplasmic copper exists as a GSH-bound complex, positioning GSH as the primary initial copper ligand following cellular uptake 167

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Cytosolic citrate can also act as a source of NADPH, either as a result of malate import into mitochondria via CIC, and the subsequent formation of pyruvate via malic enzyme, or the conversion of citrate into alpha-ketoglutarate via the action of cytosolic IDH [97, 98]