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These IGF-I actions, taken together with its neuroprotective effects following CNS and peripheral nerve injury, suggest that it may be of therapeutic benefit in a wide variety of disorders affecting the nervous system

By lowering IGF-1/insulin signaling, IF activates protective hormetic pathways, including enhanced antioxidant defenses and improved mitochondrial function

[DOI] [PubMed] [Google Scholar] 210.Shamshina J.L., Rogers R.D

48 h post-transfection or 24 h post KA treatment, cells were harvested in 500 l of the aforementioned harvesting solution and processed according to our one-pot redox metabolite and protein thiol analysis approach