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A controlled Phase III trial of dichloroacetate in children with pyruvate dehydrogenase complex deficiency (ClinicalTrials.gov ID#: NCT02616484), using a validated parental observation of child behavior scale as the primary outcome measure is undergoing result analysis and FDA review

Insight into these issues has been obtained by assessing regulatory responses triggered by the release of endogenous opioids or following exogenous administration of different opioid receptor agonists

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