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In this process, TMAO activated the NLRP3 inflammasome and NF- signaling pathway ( in vitro study found that TMAO can also upregulate the NF-B signaling pathway to promote adipogenic differentiation and inhibit the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) ( Another study found that in the aorta of fish protein-fed mice, the atherosclerotic plaque area and degree of calcification were significantly higher than that of casein- or-soy protein-fed mice, but there were no significant changes in lipid-related content

Witt KK, Clark AL, Cleland JG

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The -HPC solution was added to the medium for hydrolysis evaluation