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They decreased the expression of CD44, reduced the phosphorylation or expression of EGFR, Met, Akt, and NF-B, completely inhibited EGFR/MET-Akt/NF-B signaling activated by HGF and EGF, and showed a higher inhibition effect on cancer cells when combined with anticancer drugs cytarabine, pyirubicin, vincristine, and methotrexate [48,49,50,51]

The long-term effects on growth hormone secretion are of specific interest, as sustained rise of IGF-1 levels (whether from endogenous or exogenous sources) can suppress growth hormone release through negative feedback at the hypothalamic and pituitary levels

To gain more insight on this issue, it will be worthwhile to perform in vitro studies to test the capacity of specific isoforms to rescue the phenotypes of osteogenic cells from IGF-1 knockouts

doi: 10.1016/S0735-1097(02)01797-7