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Cardiovascular disease progression Surprisingly, both high AND low homocysteine have been associated with cardiovascular disease, though through different mechanisms: High homocysteine directly damages blood vessels Low homocysteine may indicate chronic inflammation and oxidative stress that also promote atherosclerosis The danger: You can still develop heart disease even with low homocysteine if the underlying oxidative stress and inflammation arent addressed

In summary, inflammation plays a critical role in FD, requiring ongoing research to refine treatment and management strategies, with the potential for future breakthroughs in understanding and treating this complex condition

A recent updated meta-analysis in the journal Medicine found a significant association between the MTHFR C677T variant and lung cancer susceptibility in Chinese people

Furman et al., 2012