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doi: 10.26656/fr.2017.4(6).363 239

Morning administration is often recommended for several reasons: Consistency with routine : Taking supplements with breakfast helps establish a regular habit, improving adherence Perceived energy support : Although B12 doesn't provide immediate energy, taking it in the morning aligns with the body's natural circadian rhythm when energy demands are higher Avoiding potential sleep concerns : For individuals who report feeling more alert after taking B12, morning dosing eliminates any theoretical risk of evening alertness Absorption considerations are important when choosing timing

PMID 3374544

Beyond just energy, B12 can also support a more stable mood and may even help with symptoms of depression