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This reaction simultaneously depletes two critically important metabolic cofactors: SAM (the universal methyl donor for hundreds of epigenetic and biosynthetic reactions) and nicotinamide (the precursor for NAD+ biosynthesis via the salvage pathway)

TENT-A1 Conlon et al., Sci

Liu, C., Jiang, L., Liu, L., Sun, L., Zhao, W., Chen, Y., et al., Front
