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In 2009, the EMEA (European Medicine Agency) withdrew market authorisation for rimonabant in all countries of the European Union due to safety concerns [21]

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PMCID: PMC1863555

Because its beta subunit binds to the exact same transmembrane LH/CG receptors found on target cells, researchers utilize it to bypass standard hypothalamic-pituitary-gonadal (HPG) axis signaling and directly observe downstream cellular responses