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Finally, apremilast also decreases the systemic inflammatory status of patients with psoriasis, decreasing TNF-, IFN-, IL-12, and IL-23 production (17)

[DOI] [PubMed] [Google Scholar] 85.Suzuki-Sugihara N., Kishimoto Y., Saita E., Taguchi C., Kobayashi M., Ichitani M., Ukawa Y., Sagesaka Y.M., Suzuki E., Kondo K

When organelles such as mitochondria, endoplasmic reticula (ER), and peroxisomes are damaged and dysfunctional, more ROS are produced [1, 18] in a vicious cycle [14, 24]

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