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Key genetic and molecular alterations and how they contribute to oncogenesis are discussed, such as mutations in isocitrate dehydrogenase (IDH), phosphatase and TENsin homolog (PTEN) loss with downstream PI3K/AKT/mTOR activation, and epidermal growth factor receptor (EGFR) amplification

Science 360 , 6384 (2018)

doi: 10.18632/oncotarget.20666

The network model analysis found that nodes with high connectivity, tightness, and betweenness may be the effective active metabolites s that are common to the medicinal plants and metabolites of Mongolian medicine, which is of great significance for the discovery of new effective monomer metabolites