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However, because retatrutide has the additional glucagon receptor component, starting at a lower-than-expected dose and titrating up remains the safest approach
GLP-1 in the brain stem is activated due to stress and causes a loss of appetite

Source: Gisondi, P., & Girolomoni, G

[While] the medication can be incredibly helpful, many still experience obsessive and ruminative thoughts about their bodies and food, Goldberg says
