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some people have more subcutaneous tissue in the abdomen, others in the thighs Comfort and sensitivity : Personal pain tolerance and skin sensitivity differ between body areas Lifestyle factors : Clothing, physical activity, and daily routines may make one site more practical than another It's worth noting that while the upper arm is also an approved injection site, many patients find this location difficult to self-administer and may require assistance from another person

27 In the pancreas, GLP-1 receptor (GLP-1R) activation in islet cells promotes glucose-dependent insulin secretion from -cells, 28 inhibits glucagon release from -cells, and suppresses exocrine function via induction of pancreatic somatostatin

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