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Description
Siebert S et al
Throughout the differentiation hMSC lose their spindle-like morphology and adapt to a more epithelioid shape organized in islet-like clusters [35]
Hormonal interactions: oestrogen may synergise with GLP-1 RAs to enhance appetite regulation by activating brain regions involved in controlling food intake and modifying reward pathways [55, 56]
Because tirzepatide targets both GIP and GLP-1 pathways, it often yields greater weight loss than medications targeting GLP-1 alone
